Participants took 25mg of psilocybin, reporting deeper psychological insight and better wellbeing a month later

A single dose of psilocybin, the active ingredient in magic mushrooms, can induce anatomical changes in the brain, according to research among people who took the psychedelic compound for the first time.

Scientists spotted apparent changes in the brain’s structure which were still apparent a month after healthy volunteers took the drug. If confirmed, they may help explain the therapeutic effects that psychedelics can have on anxiety, depression and addiction, researchers said.

Evidence for the changes came from specialised scans that measured the diffusion of water along nerve bundles in the brain. They suggested that some nerve tracts had become denser and more robust after the drug was taken. While the findings are preliminary, the scientists said the opposite was seen in ageing and dementia.

“It’s remarkable to see potential anatomical brain changes one month after a single dose of any drug,” said Prof Robin Carhart-Harris, a neurologist at the University of California, San Francisco, and senior author on the study. “We don’t yet know what these changes mean, but we do note that overall, people showed positive psychological changes in this study, including improved wellbeing and mental flexibility.”

  • Iconoclast@feddit.uk
    19·
    6 days ago

    This “it changes the brain” framing is somewhat misleading and sets a very low bar. Neuroplasticity is constant. Your brain is changing its structure and connections all the time in response to literally everything you do.

    • Gaywallet (they/it)@beehaw.orgM
      20·
      6 days ago

      It’s not just neuroplasticity, it’s one of very, very few things in the world that actually promotes neurogenesis. Your brain may be changing structure and connections constantly, but it’s entirely disingenuous to suggest that psychedelics aren’t causing changes that just aren’t observed from normal day-to-day life. It’s a massive dose of neurogenesis and neuroplasticity (which comes with both it’s pros an cons) and we shouldn’t minimize that just because the brain is normally a changing environment.

      Of note, many psychedelics upregulate BDNF too which has neuroprotective effects (I haven’t seen anything linking lifetime psychedelic use to things like alzheimers and general neural decline) but we know that exercise, which also upregulates BDNF, is shown to have neuroprotective effects and slow cognitive decline.