

I think the preference difference might have something to do with being used to scroll wheels or not. I personally grew up using mice with scroll wheels before I got my first touch screen device (iPod touch) so when trackpads started supporting multi-touch scroll I was already used to scrolling my fingers down to move down in the content.
For first person games, map reload on mouse 4 and sprint (or whatever else was on shift, maybe a spell) on mouse 5. Melee is left alt.