Is it safe?

I know estradiol pills fuck liver so I can fix this problem by switching to injections but I wonder if this is the case with progesterone?

I can’t do the buffing stuff every night, sorry lol.

  • LadyAutumn@lemmy.blahaj.zoneMEnglish
    10·
    2 days ago

    Take all the oral versus rectal route stuff with a grain of salt. The studies thus far have been mostly done on cis women and were measuring blood levels directly, not results. The way that progesterone interacts with stuff like breast development is not super well understood either, nor are the levels at which good development can be expected. I read a study fairly recently that suggested that there was not a large difference in satisfaction rates for patients taking it orally versus rectally, both reported positive side effects. Empirically it is hard to accurately measure things like this.

    I have tanner stage 5 breasts, and developed them to that stage before taking progesterone. My friend who takes hers rectally, and has for a couple years now, has tanner stage 4 breasts. Its anecdotal but I think is a good example of progesterone being less well understood.

    • Fei@lemmy.blahaj.zoneEnglish
      1·
      1 day ago

      Very much how I’ve been feeling about that conversation/topic. I would imagine there are many other factors that affect breast growth, and it’s unfortunately kind of impossible to know if someone’s results would have been different had they administered a different route. Genetics, age, GH levels, nutrition, etc feel like they would be the dominant factors for growth…buuut I can only assume really 🤷‍♀️ maybe libido differences could be documented one way or another. I’d be interested to know if someone who had been on hrt for a few years had introduced prog and documented any changes to libido when taking different ways.

    • Jorunn (she/her)@piefed.blahaj.zoneEnglish
      3·
      2 days ago

      I did a reading of the pharmokokinetics article on prog a while back and it is indeed very complicated. I recommend people read up on it. I used transdermal prog for a while and it seems where you apply affects whether or not it actually gets into the blood, which is not the case for estradiol. But there’s limited data for now

    • Sidal Solgun@lemmy.caOPEnglish
      3·
      2 days ago

      Thanks. I was on pills until today, do you think starting EEn soon can make changes?

      I was also exhausted tired and depressed all the time so pills are really shitty not working imo.

      I’m hopeful kinda.