Is it safe?

I know estradiol pills fuck liver so I can fix this problem by switching to injections but I wonder if this is the case with progesterone?

I can’t do the buffing stuff every night, sorry lol.

  • erin the catgirl :3 [she/her]@piefed.blahaj.zoneEnglish
    5·
    3 days ago

    oral prog long-term is safe, the main problem with is a dht backdoor, thru 5a reductase, BUTT also thru 5a reductase u will get neurosteroid - allopregnanolone, which can give mental side effects, since first-pass in liver will do a lot production to it, u want be sedated? u can try that, and huh thru liver the prog levels itself are also would be low, and lol progesterone itself can act as neurosteroid directly… https://en.wikipedia.org/wiki/Progesterone#Biological_activity

    im very sensitive to any CNS shit, and i feel a lot the mental effects of progesterone, it rly rly did good things, cuz i take it rectally, maybe it only one med which helped me a lot without tolerance in 4 days

    ALSO!!! if u take oral prog, especially a lot, check interactions with your meds especially psych ones https://en.wikipedia.org/wiki/Progesterone_(medication)#Interactions

    and yuh allopregnanolone producion can be numbed with finasteride and dutasteride(!!!, halflife 4–5 weeks, if u get sick on it, probably for long)