A large, peer-reviewed study published Friday in JAMA Network Open found that transgender youths prescribed puberty blockers had significantly lower adjusted odds of diagnosed mood disorders and suicidal thoughts and behaviors than transgender youths who did not receive the medications, adding new evidence to one of the most politically contentious areas of pediatric medicine.
The nationwide retrospective cohort study examined insurance claims data from more than 231,000 youths between 2016 and 2025, comparing transgender and cisgender youths who either did or did not receive puberty blockers.
Cis kids with precocious puberty may not be the control group they think they are. My only concern is that this could be used to gatekeep puberty blockers by scaremongering, putting the onus on kids to somehow prove they’re trans. I realise giving puberty blockers to prepubescent cis kids instead is probably massively unethical, but